The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Evidence to date suggests that opioids such as methadone may be associated with cognitive impairment. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are suggested to be neuroprotective and procognitive in the brain and may therefore counteract these effects. This study aims to explore...

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Bibliographic Details
Main Authors: Erik Nylander, Sofia Zelleroth, Fred Nyberg, Alfhild Grönbladh, Mathias Hallberg
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
growth hormone
insulin-like growth factor-1
neuroprotection
neurorecovery
cognition
primary cell cultures
methadone
opioids
Online Access:https://www.mdpi.com/1422-0067/19/11/3627

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