<b>Pancreatic islets isolated from β₂ adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients</b> - doi: 10.4025/actascibiolsci.v35i3.15842

• Main Authors: Carla Roberta de Oliveira Carvalho, Luciana Venturini Rossoni, Angelo Rafael Carpinelli, Patrícia Chakur Brum, Ana Paula Couto Davel, Anderson Carlos Marçal
• Format: Article
• Language: English
• Published: Universidade Estadual de Maringá 2013-08-01
• Series: Acta Scientiarum : Biological Sciences
• Subjects: adrenergic receptors; pancreatic beta cells; glucose, leucine
• Online Access: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842
• ISSN: 1679-9283; 1807-863X

<p>Activation of β₂ adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β₂knockout (β₂KO) mice. β₂KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β₂KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β₂KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β₂KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β₂KO mice. These results suggested a possible role of β₂ adrenergic receptors on nutrient-induced insulin secretion.</p> <p class="apalavrachave"> </p><br />