Protective effect of dexmedetomidine on endothelial barrier function in rats with sepsis

Protective effect of dexmedetomidine on endothelial barrier function in rats with sepsis

Objective To investigate the protective effects of dexmedetomidine on endothelial barrier function in rats with sepsis. Methods Sprague-Dawley rats were randomly divided into sham operation group, sepsis group, sepsis+conventional treatment group, and sepsis+dexmedetomidine group. In all but the sha...

Full description

Bibliographic Details
Main Authors:	SHE Han, FANG He, LI Tao, LIU Liangming, HU Yi
Format:	Article
Language:	zho
Published:	Editorial Office of Journal of Third Military Medical University 2020-02-01
Series:	Di-san junyi daxue xuebao
Subjects:	dexmedetomidine sepsis endothelial barrier function zonula occludes-1 pulmonary vein endothelial cells rats
Online Access:	http://aammt.tmmu.edu.cn/Upload/rhtml/201909226.htm

Similar Items

Protective Effects of Dexmedetomidine on the Vascular Endothelial Barrier Function by Inhibiting Mitochondrial Fission via ER/Mitochondria Contact
by: Han She, et al.
Published: (2021-03-01)

Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury
by: Jin Wu, et al.
Published: (2015-01-01)

Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways
by: Ming Fang, et al.
Published: (2018-08-01)

Dose-related effects of dexmedetomidine on sepsis-initiated lung injury in rats
by: Gülsüm Karabulut, et al.
Published: (2021-05-01)

Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis
by: Thijs J. Sluiter, et al.
Published: (2021-03-01)

Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology
by: Marta Martín-Fernández, et al.
Published: (2021-06-01)

Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages
by: Wang R, et al.
Published: (2021-05-01)

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
by: Yun Hou, et al.
Published: (2018-11-01)

Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage
by: Yuan Tang, et al.
Published: (2018-11-01)

Histological changes in neonatal sepsis
by: Eleonora Obinu, et al.
Published: (2014-10-01)

Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study
by: Julie Korol Wright, et al.
Published: (2018-03-01)

Differential Mechanisms of Septic Human Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Depending on the Presence of Neutrophils
by: Lefeng Wang, et al.
Published: (2018-08-01)

Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis
by: Ran X, et al.
Published: (2021-07-01)

Endothelial Microvesicles Induce Pulmonary Vascular Leakage and Lung Injury During Sepsis
by: Danyang Zheng, et al.
Published: (2020-07-01)

Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
by: Tiantian Wang, et al.
Published: (2020-12-01)

Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition
by: Yonghui Wu, et al.
Published: (2021-07-01)

Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126
by: Xia Zhang, et al.
Published: (2020-04-01)

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
by: Randy E. Strauss, et al.
Published: (2021-08-01)

Transcatheter Closure of Partially Ligated Vertical Vein after Surgical Correction of Supracardiac Total Anomalous Pulmonary Venous Connection
by: Hamid Amoozgar, et al.
Published: (2015-12-01)

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury
by: Wen-Kuang Yu, et al.
Published: (2019-01-01)

Endothelial barrier and its abnormalities in cardiovascular disease
by: Dimitry A Chistiakov, et al.
Published: (2015-12-01)

Epigenetics in Sepsis: Understanding Its Role in Endothelial Dysfunction, Immunosuppression, and Potential Therapeutics
by: Deborah Cross, et al.
Published: (2019-06-01)

Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy
by: Lijiao You, et al.
Published: (2021-05-01)

Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway
by: Qing Yu, et al.
Published: (2021-04-01)

Endothelial Activation: The Ang/Tie Axis in Sepsis
by: Aleksandra Leligdowicz, et al.
Published: (2018-04-01)

Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis
by: Tamas Csipo, et al.
Published: (2021-05-01)

Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats
by: Yun Hou, et al.
Published: (2018-10-01)

Lipid Emulsion Enhances Vasoconstriction Induced by Dexmedetomidine in the Isolated Endothelium-Intact Aorta
by: Soo Hee Lee, et al.
Published: (2021-03-01)

The Deletion of Endothelial Sodium Channel α (αENaC) Impairs Endothelium-Dependent Vasodilation and Endothelial Barrier Integrity in Endotoxemia in Vivo
by: Magdalena Sternak, et al.
Published: (2018-04-01)

Sepsis Associated Delirium
by: Ben Atterton, et al.
Published: (2020-05-01)

Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis
by: Temitayo O Idowu, et al.
Published: (2020-08-01)

Pulmonary Vein Compression After Implantation of a Left Atrial Appendage Occluder: Presentation and Discussion of a Case
by: Maryam Ayati, MD, et al.
Published: (2014-07-01)

Efficacy and safety of Xuebijing injection in the treatment of vascular endothelial injury in sepsis patients: A meta-analysis
by: Jia-Wen Zhang, et al.
Published: (2021-06-01)

Transcriptional Analysis of Sepsis-Induced Activation and Damage of the Adrenal Endothelial Microvascular Cells
by: Lan-Sun Chen, et al.
Published: (2020-01-01)

Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial
by: Yoshinori Ohta, et al.
Published: (2020-08-01)

Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy
by: Daniel S. Kikuchi, et al.
Published: (2019-11-01)

The Diagnostic and Prognostic Role of Vascular Endothelial Growth Factor C in Sepsis and Septic Shock
by: Almasy Emoke, et al.
Published: (2020-08-01)

Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions
by: Hideshi Okada, et al.
Published: (2017-10-01)

Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner
by: Bert Bosche, et al.
Published: (2016-12-01)

The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice
by: Liu Yang, et al.
Published: (2020-11-01)

Cannot write session to /tmp/vufind_sessions/sess_hpv6n60bq6s92rq830cao8k5f3