Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

• Main Authors: Rhee Jee Eun, Shin Mi Yeong, Kim Choong Mo, Kee Hye Young, Chung Jae Keun, Min Sang-Kee, Kim Seong-Joon, Jang Dai-Ho, Kim Sung Soon, Choi Byeong-Sun
• Format: Article
• Language: English
• Published: BMC 2010-08-01
• Series: Virology Journal
• Online Access: http://www.virologyj.com/content/7/1/201
• ISSN: 1743-422X

<p>Abstract</p> <p>We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women.</p>