Salmonella modulates B cell biology to evade CD8+ T cell-mediated immune responses

• Main Authors: Marcela eLopez-Medina, Araceli ePerez-Lopez, Celia eAlpuche-Aranda, Vianney eOrtiz-Navarrete
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2014-11-01
• Series: Frontiers in Immunology
• Subjects: Salmonella; B cells; CD8 T cells; cross-presentation; PD-L1
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00586/full

Although B cells and antibodies are the central effectors of humoral immunity, B cells can also produce and secrete cytokines and present antigen to helper T cells. The uptake of antigen is mainly mediated by endocytosis; thus, antigens are often presented by MHC-II molecules. However, it is unclear if B cells can present these same antigens via MHC-I molecules. Recently, Salmonella bacteria were found to infect B cells, allowing possible antigen cross-processing that could generate bacterial peptides for antigen presentation via MHC-I molecules. Here, we will discuss available knowledge regarding Salmonella antigen presentation by infected B cell MHC-I molecules and subsequent inhibitory effects on CD8+ T cells for bacterial evasion of cell-mediated immunity.