Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss

Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional con...

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Main Authors: Ying Luan, Congxiao Wang, Yun Jiao, Tianyu Tang, Jian Zhang, Gao-Jun Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00055/full
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spelling doaj-9faa94dce47544ed8d3b9e7c3d5803ef2020-11-24T22:00:28ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-02-011310.3389/fnins.2019.00055422226Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing LossYing LuanCongxiao WangYun JiaoTianyu TangJian ZhangGao-Jun TengObjects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patterns involving multiple resting-state networks (RSNs), and the correlations between the functional remodeling of RSNs and the potential cognitive or emotional impairments in SNHL.Methods: Thirty long-term bilateral SNHL patients and 39 well-matched healthy controls were recruited for assessment of resting-state functional magnetic resonance imaging and neuropsychological tests.Results: Using independent component analysis, 11 RSNs were identified. Relative to the healthy controls, patients with SNHL presented apparent abnormalities of intra-network FC involving right frontoparietal network, posterior temporal network, and sensory motor network. Disrupted between-network FC was also revealed in the SNHL patients across both higher-order cognitive control networks and multiple sensory networks. Eight of the eleven RSNs showed altered functional synchronization using a seed network to whole brain FC method, particularly in the ventromedial prefrontal cortex. In addition, these functional abnormalities were correlated with cognition- and emotion-related performances.Interpretations: These findings supported our hypotheses that long-term SNHL involves notable dysconnectivity of multiple RSNs. Our study provides important insights into the pathophysiological mechanisms of SNHL, and sheds lights on the neural substrates underlying the possible cognitive and emotional dysfunctions following SNHL.https://www.frontiersin.org/article/10.3389/fnins.2019.00055/fullsensorineural hearing lossresting-state networkfunctional reorganizationindependent component analysisfunctional connectivitycognition
collection DOAJ
language English
format Article
sources DOAJ
author Ying Luan
Congxiao Wang
Yun Jiao
Tianyu Tang
Jian Zhang
Gao-Jun Teng
spellingShingle Ying Luan
Congxiao Wang
Yun Jiao
Tianyu Tang
Jian Zhang
Gao-Jun Teng
Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
Frontiers in Neuroscience
sensorineural hearing loss
resting-state network
functional reorganization
independent component analysis
functional connectivity
cognition
author_facet Ying Luan
Congxiao Wang
Yun Jiao
Tianyu Tang
Jian Zhang
Gao-Jun Teng
author_sort Ying Luan
title Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
title_short Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
title_full Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
title_fullStr Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
title_full_unstemmed Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss
title_sort dysconnectivity of multiple resting-state networks associated with higher-order functions in sensorineural hearing loss
publisher Frontiers Media S.A.
series Frontiers in Neuroscience
issn 1662-453X
publishDate 2019-02-01
description Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patterns involving multiple resting-state networks (RSNs), and the correlations between the functional remodeling of RSNs and the potential cognitive or emotional impairments in SNHL.Methods: Thirty long-term bilateral SNHL patients and 39 well-matched healthy controls were recruited for assessment of resting-state functional magnetic resonance imaging and neuropsychological tests.Results: Using independent component analysis, 11 RSNs were identified. Relative to the healthy controls, patients with SNHL presented apparent abnormalities of intra-network FC involving right frontoparietal network, posterior temporal network, and sensory motor network. Disrupted between-network FC was also revealed in the SNHL patients across both higher-order cognitive control networks and multiple sensory networks. Eight of the eleven RSNs showed altered functional synchronization using a seed network to whole brain FC method, particularly in the ventromedial prefrontal cortex. In addition, these functional abnormalities were correlated with cognition- and emotion-related performances.Interpretations: These findings supported our hypotheses that long-term SNHL involves notable dysconnectivity of multiple RSNs. Our study provides important insights into the pathophysiological mechanisms of SNHL, and sheds lights on the neural substrates underlying the possible cognitive and emotional dysfunctions following SNHL.
topic sensorineural hearing loss
resting-state network
functional reorganization
independent component analysis
functional connectivity
cognition
url https://www.frontiersin.org/article/10.3389/fnins.2019.00055/full
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AT congxiaowang dysconnectivityofmultiplerestingstatenetworksassociatedwithhigherorderfunctionsinsensorineuralhearingloss
AT yunjiao dysconnectivityofmultiplerestingstatenetworksassociatedwithhigherorderfunctionsinsensorineuralhearingloss
AT tianyutang dysconnectivityofmultiplerestingstatenetworksassociatedwithhigherorderfunctionsinsensorineuralhearingloss
AT jianzhang dysconnectivityofmultiplerestingstatenetworksassociatedwithhigherorderfunctionsinsensorineuralhearingloss
AT gaojunteng dysconnectivityofmultiplerestingstatenetworksassociatedwithhigherorderfunctionsinsensorineuralhearingloss
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