Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
To investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between...
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Instituto Oswaldo Cruz, Ministério da Saúde
2007-02-01
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doaj-9fa5d48ff1f54ca09a4f849bf8904e4a2020-11-24T23:13:15ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602007-02-01102112112310.1590/S0074-02762007000100021S0074-02762007000100021Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central BrazilAline G Kozlowski0Ana RC Motta-Castro1Laura B Nascimento2Ágabo MC Silva3Sheila A Teles4Livia M Villar5Ana MC Gaspar6Regina MB Martins7Universidade Federal de GoiásUniversidade Federal de Mato Grosso do SulUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásFundação Oswaldo CruzFundação Oswaldo CruzUniversidade Federal de GoiásTo investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between March 2002 and November 2003. Blood samples were collected and sera were tested for HAV antibodies (total and IgM anti-HAV) by enzyme-linked immunosorbent assay. The overall prevalence of HAV infection was 75.6% (95% CI: 72.7-78.3), ranging from 55.4 to 97.3%, depending on the communities studied. The prevalence of anti-HAV increased significantly with age, from 13.8% in the age 0-5 age group to 96.6% in those older than 40 years. The findings point out an intermediate endemicity of HAV infection in some Afro-Brazilian isolated communities in Central Brazil. In addition, the high proportion of susceptible young subjects could be target of future HAV vaccination programs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100021&lng=en&tlng=enAfro-Brazilianhepatitis A virusprevalence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aline G Kozlowski Ana RC Motta-Castro Laura B Nascimento Ágabo MC Silva Sheila A Teles Livia M Villar Ana MC Gaspar Regina MB Martins |
spellingShingle |
Aline G Kozlowski Ana RC Motta-Castro Laura B Nascimento Ágabo MC Silva Sheila A Teles Livia M Villar Ana MC Gaspar Regina MB Martins Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil Memórias do Instituto Oswaldo Cruz. Afro-Brazilian hepatitis A virus prevalence |
author_facet |
Aline G Kozlowski Ana RC Motta-Castro Laura B Nascimento Ágabo MC Silva Sheila A Teles Livia M Villar Ana MC Gaspar Regina MB Martins |
author_sort |
Aline G Kozlowski |
title |
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil |
title_short |
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil |
title_full |
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil |
title_fullStr |
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil |
title_full_unstemmed |
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil |
title_sort |
prevalence of hepatitis a virus infection in afro-brazilian isolated communities in central brazil |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
1678-8060 |
publishDate |
2007-02-01 |
description |
To investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between March 2002 and November 2003. Blood samples were collected and sera were tested for HAV antibodies (total and IgM anti-HAV) by enzyme-linked immunosorbent assay. The overall prevalence of HAV infection was 75.6% (95% CI: 72.7-78.3), ranging from 55.4 to 97.3%, depending on the communities studied. The prevalence of anti-HAV increased significantly with age, from 13.8% in the age 0-5 age group to 96.6% in those older than 40 years. The findings point out an intermediate endemicity of HAV infection in some Afro-Brazilian isolated communities in Central Brazil. In addition, the high proportion of susceptible young subjects could be target of future HAV vaccination programs. |
topic |
Afro-Brazilian hepatitis A virus prevalence |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100021&lng=en&tlng=en |
work_keys_str_mv |
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