Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil

To investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between...

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Main Authors: Aline G Kozlowski, Ana RC Motta-Castro, Laura B Nascimento, Ágabo MC Silva, Sheila A Teles, Livia M Villar, Ana MC Gaspar, Regina MB Martins
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2007-02-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100021&lng=en&tlng=en
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spelling doaj-9fa5d48ff1f54ca09a4f849bf8904e4a2020-11-24T23:13:15ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602007-02-01102112112310.1590/S0074-02762007000100021S0074-02762007000100021Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central BrazilAline G Kozlowski0Ana RC Motta-Castro1Laura B Nascimento2Ágabo MC Silva3Sheila A Teles4Livia M Villar5Ana MC Gaspar6Regina MB Martins7Universidade Federal de GoiásUniversidade Federal de Mato Grosso do SulUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásFundação Oswaldo CruzFundação Oswaldo CruzUniversidade Federal de GoiásTo investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between March 2002 and November 2003. Blood samples were collected and sera were tested for HAV antibodies (total and IgM anti-HAV) by enzyme-linked immunosorbent assay. The overall prevalence of HAV infection was 75.6% (95% CI: 72.7-78.3), ranging from 55.4 to 97.3%, depending on the communities studied. The prevalence of anti-HAV increased significantly with age, from 13.8% in the age 0-5 age group to 96.6% in those older than 40 years. The findings point out an intermediate endemicity of HAV infection in some Afro-Brazilian isolated communities in Central Brazil. In addition, the high proportion of susceptible young subjects could be target of future HAV vaccination programs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100021&lng=en&tlng=enAfro-Brazilianhepatitis A virusprevalence
collection DOAJ
language English
format Article
sources DOAJ
author Aline G Kozlowski
Ana RC Motta-Castro
Laura B Nascimento
Ágabo MC Silva
Sheila A Teles
Livia M Villar
Ana MC Gaspar
Regina MB Martins
spellingShingle Aline G Kozlowski
Ana RC Motta-Castro
Laura B Nascimento
Ágabo MC Silva
Sheila A Teles
Livia M Villar
Ana MC Gaspar
Regina MB Martins
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
Memórias do Instituto Oswaldo Cruz.
Afro-Brazilian
hepatitis A virus
prevalence
author_facet Aline G Kozlowski
Ana RC Motta-Castro
Laura B Nascimento
Ágabo MC Silva
Sheila A Teles
Livia M Villar
Ana MC Gaspar
Regina MB Martins
author_sort Aline G Kozlowski
title Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
title_short Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
title_full Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
title_fullStr Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
title_full_unstemmed Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil
title_sort prevalence of hepatitis a virus infection in afro-brazilian isolated communities in central brazil
publisher Instituto Oswaldo Cruz, Ministério da Saúde
series Memórias do Instituto Oswaldo Cruz.
issn 1678-8060
publishDate 2007-02-01
description To investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between March 2002 and November 2003. Blood samples were collected and sera were tested for HAV antibodies (total and IgM anti-HAV) by enzyme-linked immunosorbent assay. The overall prevalence of HAV infection was 75.6% (95% CI: 72.7-78.3), ranging from 55.4 to 97.3%, depending on the communities studied. The prevalence of anti-HAV increased significantly with age, from 13.8% in the age 0-5 age group to 96.6% in those older than 40 years. The findings point out an intermediate endemicity of HAV infection in some Afro-Brazilian isolated communities in Central Brazil. In addition, the high proportion of susceptible young subjects could be target of future HAV vaccination programs.
topic Afro-Brazilian
hepatitis A virus
prevalence
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100021&lng=en&tlng=en
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