Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis

Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis

A 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range o...

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Main Authors: Takayuki Wakabayashi, Noriko Sasaki, Naofumi Chinen, Yasuo Suzuki
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2015/817592
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spelling doaj-9f9eed20b8984706a46af4f0f71c6c892020-11-24T22:43:58ZengHindawi LimitedCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/817592817592Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile DermatomyositisTakayuki Wakabayashi0Noriko Sasaki1Naofumi Chinen2Yasuo Suzuki3Department of Rheumatology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji 192-0032, JapanDepartment of Rheumatology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji 192-0032, JapanDivision of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanDivision of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanA 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range of knee joint motion and resultant disturbance of daily activities. Cimetidine was combined with intermittent administration of high-dose etidronate, leading to marked improvement of both subcutaneous and muscular calcinosis with no skeletal adverse reactions during a long treatment period exceeding 5 years. As a result, the range of knee joint motion has increased and performance of daily activities has improved.http://dx.doi.org/10.1155/2015/817592
collection DOAJ
language English
format Article
sources DOAJ
author Takayuki Wakabayashi
Noriko Sasaki
Naofumi Chinen
Yasuo Suzuki
spellingShingle Takayuki Wakabayashi
Noriko Sasaki
Naofumi Chinen
Yasuo Suzuki
Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
Case Reports in Rheumatology
author_facet Takayuki Wakabayashi
Noriko Sasaki
Naofumi Chinen
Yasuo Suzuki
author_sort Takayuki Wakabayashi
title Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
title_short Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
title_full Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
title_fullStr Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
title_full_unstemmed Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
title_sort dramatic improvement of subcutaneous calcinosis by intermittent, high-dose etidronate plus cimetidine in a patient with juvenile dermatomyositis
publisher Hindawi Limited
series Case Reports in Rheumatology
issn 2090-6889
2090-6897
publishDate 2015-01-01
description A 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range of knee joint motion and resultant disturbance of daily activities. Cimetidine was combined with intermittent administration of high-dose etidronate, leading to marked improvement of both subcutaneous and muscular calcinosis with no skeletal adverse reactions during a long treatment period exceeding 5 years. As a result, the range of knee joint motion has increased and performance of daily activities has improved.
url http://dx.doi.org/10.1155/2015/817592
work_keys_str_mv AT takayukiwakabayashi dramaticimprovementofsubcutaneouscalcinosisbyintermittenthighdoseetidronatepluscimetidineinapatientwithjuveniledermatomyositis
AT norikosasaki dramaticimprovementofsubcutaneouscalcinosisbyintermittenthighdoseetidronatepluscimetidineinapatientwithjuveniledermatomyositis
AT naofumichinen dramaticimprovementofsubcutaneouscalcinosisbyintermittenthighdoseetidronatepluscimetidineinapatientwithjuveniledermatomyositis
AT yasuosuzuki dramaticimprovementofsubcutaneouscalcinosisbyintermittenthighdoseetidronatepluscimetidineinapatientwithjuveniledermatomyositis
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