Clinical application of estimating hepatitis B virus quasispecies complexity by massive sequencing: correlation between natural evolution and on-treatment evolution.

Clinical application of estimating hepatitis B virus quasispecies complexity by massive sequencing: correlation between natural evolution and on-treatment evolution.

<h4>Aim</h4>To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment.<h4>Methods</h4>Ultra-deep pyrosequencing of HBV preCore/Core regions in 30...

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Bibliographic Details
Main Authors: Maria Homs, Andrea Caballero, Josep Gregori, David Tabernero, Josep Quer, Leonardo Nieto, Rafael Esteban, Maria Buti, Francisco Rodriguez-Frias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0112306

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