The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis

The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis

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Background: Reactive oxygen species (ROS) have important role in the etiology and pathogenesis of Rheumatoid Arthritis (RA). We investigated the effect of conjugated linoleic acids (CLAs) and vitamin E on lipid peroxidation. Methods: In a randomized, double-blind placebo, controlled, clinical trial...

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Main Authors: N Aryaeian, M Djalali, F Shahram, A Djazayeri, MR Eshragian, N Nadery, F Fatehi, M Zarei, M Chamari
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2009-06-01
Series:Iranian Journal of Public Health
Subjects:
Conjugated linoleic acid
Vitamin E
Lipid peroxidation
Active rheumatoid arthritis
Online Access:https://ijph.tums.ac.ir/index.php/ijph/article/view/3192
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spelling doaj-9f95d0de1522464295ec604f0a60c4c32020-12-02T18:55:51ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932009-06-01382The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid ArthritisN Aryaeian 0M Djalali 1F Shahram 2A Djazayeri 3MR Eshragian4N Nadery 5F Fatehi 6M Zarei7M Chamari 8Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, IranDept. of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences,Rheumatology Research Center, Shariaty Hospital, Tehran University of Medical Sciences, Iran2Dept. of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical SciencesDept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical ScienRheumatology Research Center, Shariaty Hospital, Tehran University of Medical Sciences, IranDept. of Nutrition, School of Public Health, Iran University of Medical Sciences, IranDept. of Nutrition, School of Public Health, Iran University of Medical Sciences, IranDept. of Nutrition, School of Public Health, Iran University of Medical Sciences, IranBackground: Reactive oxygen species (ROS) have important role in the etiology and pathogenesis of Rheumatoid Arthritis (RA). We investigated the effect of conjugated linoleic acids (CLAs) and vitamin E on lipid peroxidation. Methods: In a randomized, double-blind placebo, controlled, clinical trial 87 patients with active RA were enrolled. They were divided into 4 groups, received one of the following daily supplement for 3 months; 1- group C: 2.5gr CLA, that con­tained 2 gr 50:50 mix of cis 9-trans11 and trans 10-cis 12 CLAs, 2- group E: 400mg Vitamin E, 3- group CE: CLAs  plus vita­min E, 4- group P: placebo. After supplementation Glutathione peroxidase (GSH-Px) level increased in C, E and CE groups, CE group had  lower GSH-Px than P group(P≤ 0.05). Results: Glutathione reductase (GR) increased in CE, C and P groups. Catalase increased in all groups, but enhancement was significant in C and CE. Superoxide dismutase (SOD) decreased in E and C (P≤ 0.05). Catalase and SOD did not show signifi­cant differences between groups. Malondialdehyde (MDA) decreased significantly in all groups but this decrease was only significant in CE in comparison with other groups. Conclusion:  CLAs might be useful in reducing oxidative stress in RA https://ijph.tums.ac.ir/index.php/ijph/article/view/3192Conjugated linoleic acidVitamin ELipid peroxidationActive rheumatoid arthritis
collection DOAJ
language English
format Article
sources DOAJ
author N Aryaeian
M Djalali
F Shahram
A Djazayeri
MR Eshragian
N Nadery
F Fatehi
M Zarei
M Chamari
spellingShingle N Aryaeian
M Djalali
F Shahram
A Djazayeri
MR Eshragian
N Nadery
F Fatehi
M Zarei
M Chamari
The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
Iranian Journal of Public Health
Conjugated linoleic acid
Vitamin E
Lipid peroxidation
Active rheumatoid arthritis
author_facet N Aryaeian
M Djalali
F Shahram
A Djazayeri
MR Eshragian
N Nadery
F Fatehi
M Zarei
M Chamari
author_sort N Aryaeian
title The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
title_short The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
title_full The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
title_fullStr The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
title_full_unstemmed The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis
title_sort effect of conjugated linoleic acids, vitamin e and their com¬bination on lipid peroxidation in active rheumatoid arthritis
publisher Tehran University of Medical Sciences
series Iranian Journal of Public Health
issn 2251-6085
2251-6093
publishDate 2009-06-01
description Background: Reactive oxygen species (ROS) have important role in the etiology and pathogenesis of Rheumatoid Arthritis (RA). We investigated the effect of conjugated linoleic acids (CLAs) and vitamin E on lipid peroxidation. Methods: In a randomized, double-blind placebo, controlled, clinical trial 87 patients with active RA were enrolled. They were divided into 4 groups, received one of the following daily supplement for 3 months; 1- group C: 2.5gr CLA, that con­tained 2 gr 50:50 mix of cis 9-trans11 and trans 10-cis 12 CLAs, 2- group E: 400mg Vitamin E, 3- group CE: CLAs  plus vita­min E, 4- group P: placebo. After supplementation Glutathione peroxidase (GSH-Px) level increased in C, E and CE groups, CE group had  lower GSH-Px than P group(P≤ 0.05). Results: Glutathione reductase (GR) increased in CE, C and P groups. Catalase increased in all groups, but enhancement was significant in C and CE. Superoxide dismutase (SOD) decreased in E and C (P≤ 0.05). Catalase and SOD did not show signifi­cant differences between groups. Malondialdehyde (MDA) decreased significantly in all groups but this decrease was only significant in CE in comparison with other groups. Conclusion:  CLAs might be useful in reducing oxidative stress in RA
topic Conjugated linoleic acid
Vitamin E
Lipid peroxidation
Active rheumatoid arthritis
url https://ijph.tums.ac.ir/index.php/ijph/article/view/3192
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