Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?

Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?

We describe an adolescent girl with non-paraneoplastic anti-NMDA-receptor encephalitis (ANMDARE), who despite persistence of the extreme delta brush (EDB) pattern for nearly 2 years in her serial EEGs, she exhibited a speedy and sustained response to immunotherapy. To the best of our knowledge, our...

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Main Authors: Muthukani Sankaranarayanan, Shalin Shah, Pravin Thomas, Sudheeran Kannoth, Kurupath Radhakrishnan
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Epilepsy & Behavior Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2589986419300656
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spelling doaj-9f943628bc454143bff93cf539592ac32020-11-25T02:13:23ZengElsevierEpilepsy & Behavior Reports2589-98642019-01-0112Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?Muthukani Sankaranarayanan0Shalin Shah1Pravin Thomas2Sudheeran Kannoth3Kurupath Radhakrishnan4Department of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaDepartment of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaDepartment of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaDepartment of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaCorresponding author at: Department of Neurosciences, Avitis Institute of Medical Sciences, Nemmara, Palakkad 678 508, Kerala, India.; Department of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaWe describe an adolescent girl with non-paraneoplastic anti-NMDA-receptor encephalitis (ANMDARE), who despite persistence of the extreme delta brush (EDB) pattern for nearly 2 years in her serial EEGs, she exhibited a speedy and sustained response to immunotherapy. To the best of our knowledge, our patient had the longest persistence of the EDB pattern on EEG reported to date. Our patient illustrates that, although presence of EDB supports the diagnosis of ANMDARE, its presence and persistence may not be a reliable predictor of response to immunotherapy and overall clinical prognosis. Keywords: Anti-NMDA-R encephalitis, Autoimmune encephalitis, Electroencephalography (EEG), Extreme delta brush, Gerstmann syndrome, Immunotherapyhttp://www.sciencedirect.com/science/article/pii/S2589986419300656
collection DOAJ
language English
format Article
sources DOAJ
author Muthukani Sankaranarayanan
Shalin Shah
Pravin Thomas
Sudheeran Kannoth
Kurupath Radhakrishnan
spellingShingle Muthukani Sankaranarayanan
Shalin Shah
Pravin Thomas
Sudheeran Kannoth
Kurupath Radhakrishnan
Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
Epilepsy & Behavior Reports
author_facet Muthukani Sankaranarayanan
Shalin Shah
Pravin Thomas
Sudheeran Kannoth
Kurupath Radhakrishnan
author_sort Muthukani Sankaranarayanan
title Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
title_short Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
title_full Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
title_fullStr Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
title_full_unstemmed Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
title_sort persistent extreme delta brush in anti-nmda-receptor encephalitis: does it portend a poor prognosis?
publisher Elsevier
series Epilepsy & Behavior Reports
issn 2589-9864
publishDate 2019-01-01
description We describe an adolescent girl with non-paraneoplastic anti-NMDA-receptor encephalitis (ANMDARE), who despite persistence of the extreme delta brush (EDB) pattern for nearly 2 years in her serial EEGs, she exhibited a speedy and sustained response to immunotherapy. To the best of our knowledge, our patient had the longest persistence of the EDB pattern on EEG reported to date. Our patient illustrates that, although presence of EDB supports the diagnosis of ANMDARE, its presence and persistence may not be a reliable predictor of response to immunotherapy and overall clinical prognosis. Keywords: Anti-NMDA-R encephalitis, Autoimmune encephalitis, Electroencephalography (EEG), Extreme delta brush, Gerstmann syndrome, Immunotherapy
url http://www.sciencedirect.com/science/article/pii/S2589986419300656
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