Solubility Enhancement and Formulation of Mouth Dissolving Tablet of Clonazepam with Solid Dispersion Technology

Solubility Enhancement and Formulation of Mouth Dissolving Tablet of Clonazepam with Solid Dispersion Technology

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Clonazepam (CLZ) is an anticonvulsant benzodiazepine widely used in the treatment of epilepsy. CLZ is a BCS Class II drug and its bioavailability is thus dissolution limited. The objective of the present study was to prepare solid dispersions (SDs) of CLZ by various techniques, using the amphiphilic...

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Bibliographic Details
Main Authors:	Swati C. Jagdale, Ajay S. Bhadoriya, Aniruddha R. Chabukswar
Format:	Article
Language:	English
Published:	São Paulo State University (UNESP) 2012-01-01
Series:	Revista de Ciências Farmacêuticas Básica e Aplicada
Subjects:	clonazepam, gelucire 50/13. solid dispersions. kneading. tablet. ftir.
Online Access:	http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/312

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