Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort

Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort

Abstract Background The cerebrospinal fluid (CSF) levels of total tau (t-tau) and Aβ1–42 are potential early diagnostic markers for probable Alzheimer’s disease (AD). The influence of genetic variation on these CSF biomarkers has been investigated in candidate or genome-wide association studies (GWA...

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Main Authors: Wang Cong, Xianglian Meng, Jin Li, Qiushi Zhang, Feng Chen, Wenjie Liu, Ying Wang, Sipu Cheng, Xiaohui Yao, Jingwen Yan, Sungeun Kim, Andrew J. Saykin, Hong Liang, Li Shen, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Genomics
Subjects:
Alzhermer’s disease
CSF biomarker
t-tau/Aβ1–42 ratio
Network analysis
Pathway analysis
Consensus module
Online Access:http://link.springer.com/article/10.1186/s12864-017-3798-z

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http://link.springer.com/article/10.1186/s12864-017-3798-z

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