From experimental biomodeling to personalized medicine

• Main Authors: V. S. Rukavishnikov, L. M. Sosedova, E. A. Kapustina, V. A. Vokina, E. A. Titov, N. L. Yakimova
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2013-05-01
• Series: Acta Biomedica Scientifica
• Subjects: albino rats; vinyl chloride; mercuric chloride; toluene; prenatal hypoxia; descendants; nervous system
• Online Access: https://www.actabiomedica.ru/jour/article/view/1504
• ISSN: 2541-9420; 2587-9596

This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation.