Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents

Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents

The reticular activating system (RAS) of the brainstem regulates wakefulness, and stimulation of RAS areas can reverse effects of anaesthesia. Here, the authors show that stimulation of a particular RAS area, the anterior portion of nucleus gigantocellularis, can produce arousal from deep coma.

Bibliographic Details
Main Authors: S. Gao, A. Proekt, N. Renier, D. P. Calderon, D. W. Pfaff
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10797-7
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spelling doaj-9f743d8f239245c0a4937e673cd9d5252021-05-11T11:43:24ZengNature Publishing GroupNature Communications2041-17232019-07-0110111410.1038/s41467-019-10797-7Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodentsS. Gao0A. Proekt1N. Renier2D. P. Calderon3D. W. Pfaff4Department of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeICM, Brain and Spine Institute, Hopital de la Pitie-Salpetriere, Sorbonne Universite, Inserm, CNRSDepartment of Anesthesiology, Weill Cornell Medical CollegeLaboratory of Neurobiology and Behavior, the Rockefeller UniversityThe reticular activating system (RAS) of the brainstem regulates wakefulness, and stimulation of RAS areas can reverse effects of anaesthesia. Here, the authors show that stimulation of a particular RAS area, the anterior portion of nucleus gigantocellularis, can produce arousal from deep coma.https://doi.org/10.1038/s41467-019-10797-7
collection DOAJ
language English
format Article
sources DOAJ
author S. Gao
A. Proekt
N. Renier
D. P. Calderon
D. W. Pfaff
spellingShingle S. Gao
A. Proekt
N. Renier
D. P. Calderon
D. W. Pfaff
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
Nature Communications
author_facet S. Gao
A. Proekt
N. Renier
D. P. Calderon
D. W. Pfaff
author_sort S. Gao
title Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
title_short Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
title_full Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
title_fullStr Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
title_full_unstemmed Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
title_sort activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description The reticular activating system (RAS) of the brainstem regulates wakefulness, and stimulation of RAS areas can reverse effects of anaesthesia. Here, the authors show that stimulation of a particular RAS area, the anterior portion of nucleus gigantocellularis, can produce arousal from deep coma.
url https://doi.org/10.1038/s41467-019-10797-7
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AT nrenier activatingananteriornucleusgigantocellularissubpopulationtriggersemergencefrompharmacologicallyinducedcomainrodents
AT dpcalderon activatingananteriornucleusgigantocellularissubpopulationtriggersemergencefrompharmacologicallyinducedcomainrodents
AT dwpfaff activatingananteriornucleusgigantocellularissubpopulationtriggersemergencefrompharmacologicallyinducedcomainrodents
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