Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure
Early diagnosis and management of cerebral edema in acute liver failure is important to reduce neurological complication and mortality. Ammonia-induced astrocyte swelling and increased blood brain barrier permeability via transmembrane dysfunction are major mechanisms of cerebral edema in acute live...
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The Korean Neurocritical Care Society
2016-12-01
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| Series: | Journal of Neurocritical Care |
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| Online Access: | http://www.e-jnc.org/upload/pdf/jnc-160088.pdf |
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doaj-9f69d2085649464a81bceb4eecc6b14e2020-11-25T01:56:14ZengThe Korean Neurocritical Care SocietyJournal of Neurocritical Care2005-03482508-13492016-12-0192637010.18700/jnc.160088241Pathophysiology and Treatment of Cerebral Edema in Acute Liver FailureSe Young Jang0Jun Young Chang1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, KoreaDepartment of Neurology, Gyeongsang National University Changwon Hospital, Changwon, KoreaEarly diagnosis and management of cerebral edema in acute liver failure is important to reduce neurological complication and mortality. Ammonia-induced astrocyte swelling and increased blood brain barrier permeability via transmembrane dysfunction are major mechanisms of cerebral edema in acute liver failure. Conventional therapy can be used to lower intracranial pressure. In addition, various treatment options are available to reduce serum ammonia level. Herein, we described the pathophysiology, monitoring, and management of cerebral edema in acute liver failure.http://www.e-jnc.org/upload/pdf/jnc-160088.pdfLiver failure, AcuteBrain edemaPhysiopathologyTherapy |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Se Young Jang Jun Young Chang |
| spellingShingle |
Se Young Jang Jun Young Chang Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure Journal of Neurocritical Care Liver failure, Acute Brain edema Physiopathology Therapy |
| author_facet |
Se Young Jang Jun Young Chang |
| author_sort |
Se Young Jang |
| title |
Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure |
| title_short |
Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure |
| title_full |
Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure |
| title_fullStr |
Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure |
| title_full_unstemmed |
Pathophysiology and Treatment of Cerebral Edema in Acute Liver Failure |
| title_sort |
pathophysiology and treatment of cerebral edema in acute liver failure |
| publisher |
The Korean Neurocritical Care Society |
| series |
Journal of Neurocritical Care |
| issn |
2005-0348 2508-1349 |
| publishDate |
2016-12-01 |
| description |
Early diagnosis and management of cerebral edema in acute liver failure is important to reduce neurological complication and mortality. Ammonia-induced astrocyte swelling and increased blood brain barrier permeability via transmembrane dysfunction are major mechanisms of cerebral edema in acute liver failure. Conventional therapy can be used to lower intracranial pressure. In addition, various treatment options are available to reduce serum ammonia level. Herein, we described the pathophysiology, monitoring, and management of cerebral edema in acute liver failure. |
| topic |
Liver failure, Acute Brain edema Physiopathology Therapy |
| url |
http://www.e-jnc.org/upload/pdf/jnc-160088.pdf |
| work_keys_str_mv |
AT seyoungjang pathophysiologyandtreatmentofcerebraledemainacuteliverfailure AT junyoungchang pathophysiologyandtreatmentofcerebraledemainacuteliverfailure |
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1724980704503136256 |