Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetylcholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rat...

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Bibliographic Details
Main Authors: Saša R. Ivanović, Blagoje Dimitrijević, Vitomir Ćupić, Milanka Jezdimirović, Sunčica Borozan, Mila Savić, Djordje Savić
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Toxicology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750016300440

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