Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification. Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involv...

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Bibliographic Details
Main Authors:	C. Mary, F. Faraut, M. Deniau, J. Dereure, K. Aoun, S. Ranque, R. Piarroux
Format:	Article
Language:	English
Published:	Hindawi Limited 2010-01-01
Series:	International Journal of Microbiology
Online Access:	http://dx.doi.org/10.1155/2010/819060

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