Reconstitution of ovarian function following transplantation of primordial germ cells

Abstract Ovarian aging occurs earlier than somatic aging. We tested the hypothesis that ovarian functions could be artificially reconstructed by transplantation of primordial germ cells (PGCs). We compared various methods for transplantation of PGCs aggregated with gonadal somatic cells and showed t...

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Bibliographic Details
Main Authors: Ming Zeng, Xiaoyan Sheng, David L. Keefe, Lin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01648-w