FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

BackgroundIntervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus (FK506) is a potent immunosuppressive agent that is also beneficial to chondrocytes via alleviating inflammation. However,...

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Bibliographic Details
Main Authors: Jun Ge, Yingjie Wang, Qi Yan, Cenhao Wu, Hao Yu, Huilin Yang, Jun Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
FK506
disk degeneration
TGFβ
Smad3
signal pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.608308/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.608308/full

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