Syndrome of inappropriate antidiuretic hormone secretion as a side effect of chemotherapy for testicular cancer: A case report

• Main Authors: Koki Maeda, Susumu Kageyama, Takashi Osafune, Yoshikata Masuda, Shota Nakagawa, Kenji Miki, Shun Esumi, Maiko Kakita‐Kobayashi, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi
• Format: Article
• Language: English
• Published: Wiley 2019-11-01
• Series: IJU Case Reports
• Subjects: syndrome of inappropriate antidiuretic hormone secretion; chemotherapy; hyponatremia; renal salt wasting syndrome; testicular cancer
• Online Access: https://doi.org/10.1002/iju5.12122

Introduction Inappropriate antidiuretic hormone secretion syndrome can be a serious adverse event of cisplatin‐based chemotherapy. Cisplatin had to be changed to other drugs or chemotherapy completely discontinued in earlier reported cases. Case presentation Three cycles of bleomycin, etoposide, and cisplatin chemotherapy were planned for a 40‐year‐old man with a diagnosis of lymph node recurrence of testicular cancer. On day 9, he suffered from vomiting and mental disturbance. Severe hyponatremia (110 mEq/L) with low plasma osmolality led to a diagnosis of a syndrome of inappropriate antidiuretic hormone secretion, and infusions of hypertonic saline and salt intake were prescribed. Second and third courses of bleomycin, etoposide, and cisplatin chemotherapy could then be given with careful electrolyte management. Conclusion Continuation of cisplatin administration with precise electrolyte adjustment can be a treatment option in regimens where cisplatin is essential for achieving optimal antitumor efficacy.