Analgesic effectiveness and safety of single-dose intrathecal morphine

• Main Authors: Yasel González Brizuela, Katia Velázquez González, Teddy Osmín Tamargo Barbeito
• Format: Article
• Language: Spanish
• Published: Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED) 2017-09-01
• Series: Revista Cubana de Anestesiología y Reanimación
• Subjects: morfina intratecal; dolor posoperatorio
• Online Access: http://www.revanestesia.sld.cu/index.php/anestRean/article/view/195

<span style="font-family: Verdana; font-size: small;"><strong>Introduction:</strong> The superior hemiabdomen postoperative pain is severe and essential to be managed in order to avoid complications.<br /> <strong>Objectives:</strong> To assess the analgesic effectiveness and safety of single-dose intrathecal morphine in the postoperative period of the upper hemiabdomen major surgery.<br /> <strong>Method: </strong>Single-blind randomized clinical trial in 40 patients, after upper hemiabdomen interventions. We used single doses of intrathecal morphine (ITM) of 1 or 2 mg/kg per patient weight according to the treatment group. The statistical analysis used the Chi-square test, Fisher's exact test, univariate analysis of variance, Mauchly's test and Univariate F-test; the significance level was 0.05.<br /> <strong>Results:</strong> Opioids administration during surgery was similar in both groups (3.1 ± 2.2 mL <em>vs.</em> 4.1 ± 2.7 mL). In the 2 mg/kg of ITM dose group, the patients reported no pain after 12 and 14 hours; there were differences between treatments regarding pain relief (p&lt; 0.001) and also between the time when it was measured (p= 0.001). Rescue analgesia was used in 25 % of the patients. Respiratory depression was the only onset complication.<br /> <strong>Conclusions:</strong> ITM at a single dose of 2 μg/kg is an effective method for postoperative analgesia in upper hemiabdomen surgery, the incidence of complications was low and both doses proved safe.</span>