Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

Lipopolysaccharides (LPS) are synthesized at the periplasmic side of the inner membrane of Gram-negative bacteria and are then extracted by the LptB2FG complex during the first step of LPS transport to the outer membrane. Here the authors present the LptB2FG structure, which supports an alternating...

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Main Authors: Haohao Dong, Zhengyu Zhang, Xiaodi Tang, Neil G. Paterson, Changjiang Dong
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00273-5
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spelling doaj-9f348f6efa4b41969dce2efed310a4892021-01-31T12:25:43ZengNature Publishing GroupNature Communications2041-17232017-08-018111110.1038/s41467-017-00273-5Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FGHaohao Dong0Zhengyu Zhang1Xiaodi Tang2Neil G. Paterson3Changjiang Dong4State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of BiotherapyBiomedical Research Centre, Norwich Medical School, University of East AngliaBiomedical Research Centre, Norwich Medical School, University of East AngliaDiamond Light Source, Harwell Science and Innovation CampusBiomedical Research Centre, Norwich Medical School, University of East AngliaLipopolysaccharides (LPS) are synthesized at the periplasmic side of the inner membrane of Gram-negative bacteria and are then extracted by the LptB2FG complex during the first step of LPS transport to the outer membrane. Here the authors present the LptB2FG structure, which supports an alternating lateral access mechanism for LPS extraction.https://doi.org/10.1038/s41467-017-00273-5
collection DOAJ
language English
format Article
sources DOAJ
author Haohao Dong
Zhengyu Zhang
Xiaodi Tang
Neil G. Paterson
Changjiang Dong
spellingShingle Haohao Dong
Zhengyu Zhang
Xiaodi Tang
Neil G. Paterson
Changjiang Dong
Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
Nature Communications
author_facet Haohao Dong
Zhengyu Zhang
Xiaodi Tang
Neil G. Paterson
Changjiang Dong
author_sort Haohao Dong
title Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
title_short Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
title_full Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
title_fullStr Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
title_full_unstemmed Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
title_sort structural and functional insights into the lipopolysaccharide abc transporter lptb2fg
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Lipopolysaccharides (LPS) are synthesized at the periplasmic side of the inner membrane of Gram-negative bacteria and are then extracted by the LptB2FG complex during the first step of LPS transport to the outer membrane. Here the authors present the LptB2FG structure, which supports an alternating lateral access mechanism for LPS extraction.
url https://doi.org/10.1038/s41467-017-00273-5
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AT zhengyuzhang structuralandfunctionalinsightsintothelipopolysaccharideabctransporterlptb2fg
AT xiaoditang structuralandfunctionalinsightsintothelipopolysaccharideabctransporterlptb2fg
AT neilgpaterson structuralandfunctionalinsightsintothelipopolysaccharideabctransporterlptb2fg
AT changjiangdong structuralandfunctionalinsightsintothelipopolysaccharideabctransporterlptb2fg
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