Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons

Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons

Recently an aspartyl protease with β-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT2 neurons to the two classical pro-oxidant stimuli ascorbate/FeSO4 and H2O2/FeSO4 resulted i...

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Bibliographic Details
Main Authors: Elena Tamagno, Paola Bardini, Alessandra Obbili, Antonella Vitali, Roberta Borghi, Damiano Zaccheo, Maria A. Pronzato, Oliviero Danni, Mark A. Smith, George Perry, Massimo Tabaton
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Neurobiology of Disease
Subjects:
BACE
Alzheimer's disease
HNE
NT2 neurons
oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905152

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http://www.sciencedirect.com/science/article/pii/S0969996102905152

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