Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcr...
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Bibliographic Details
| Main Authors: |
Anat Shemer,
Jonathan Grozovski,
Tuan Leng Tay,
Jenhan Tao,
Alon Volaski,
Patrick Süß,
Alberto Ardura-Fabregat,
Mor Gross-Vered,
Jung-Seok Kim,
Eyal David,
Louise Chappell-Maor,
Lars Thielecke,
Christopher K. Glass,
Kerstin Cornils,
Marco Prinz,
Steffen Jung |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07548-5
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