Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy

Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy

Protein-protein interactions (PPIs) regulate a plethora of cellular processes and NMR spectroscopy has been a leading technique for characterizing them at the atomic resolution. Technically, however, PPIs characterization has been challenging due to multiple samples required to characterize the hot...

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Bibliographic Details
Main Authors: Erik K. Larsen, Cristina Olivieri, Caitlin Walker, Manu V.S., Jiali Gao, David A. Bernlohr, Marco Tonelli, John L. Markley, Gianluigi Veglia
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
protein-protein interactions (PPI)
nuclear magnetic resonance (NMR)
Carbonyl Carbon Label Selective (CCLS)
dual carbon label selective (DCLS)
residual dipolar coupling (RDC)
paramagnetic relaxation enhancement (PRE)
Online Access:http://www.mdpi.com/1420-3049/23/8/1937

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