Characterization of Human Dosage-Sensitive Transcription Factor Genes

Characterization of Human Dosage-Sensitive Transcription Factor Genes

Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expressio...

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Bibliographic Details
Main Authors: Zhihua Ni, Xiao-Yu Zhou, Sidra Aslam, Deng-Ke Niu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Genetics
Subjects:
transcription factor
dosage-sensitive
ohnolog
conserved copy number
haploinsufficiency
disease
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01208/full

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