SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes

SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes

During brain development, sodium–vitamin C transporter (SVCT2) has been detected primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex neuroblasts. However, strong SVCT2 expression is observed during the first postnatal days, resulting in increased intracellular c...

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Bibliographic Details
Main Authors: Katterine Salazar, Francisca Espinoza, Gustavo Cerda-Gallardo, Luciano Ferrada, Rocío Magdalena, Eder Ramírez, Viviana Ulloa, Natalia Saldivia, Ninoschka Troncoso, María José Oviedo, María José Barahona, Fernando Martínez, Francisco Nualart
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antioxidants
Subjects:
SVCT2
vitamin C
ascorbic acid
dehydroascorbic acid
cortical neurons
neurospheres
Online Access:https://www.mdpi.com/2076-3921/10/9/1413

Internet

https://www.mdpi.com/2076-3921/10/9/1413

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