Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors

For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.

Bibliographic Details
Main Authors:	Ye Chen, Joanne M. L. Ho, David L. Shis, Chinmaya Gupta, James Long, Daniel S. Wagner, William Ott, Krešimir Josić, Matthew R. Bennett
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02473-5

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spelling	doaj-9f191ec1c7d248d3bde26396083e9a7b2021-05-11T09:56:35ZengNature Publishing GroupNature Communications2041-17232018-01-01911810.1038/s41467-017-02473-5Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factorsYe Chen0Joanne M. L. Ho1David L. Shis2Chinmaya Gupta3James Long4Daniel S. Wagner5William Ott6Krešimir Josić7Matthew R. Bennett8Department of Biosciences, Rice UniversityDepartment of Biosciences, Rice UniversityDepartment of Biosciences, Rice UniversityDepartment of Mathematics, University of HoustonDepartment of Biosciences, Rice UniversityDepartment of Biosciences, Rice UniversityDepartment of Mathematics, University of HoustonDepartment of Biosciences, Rice UniversityDepartment of Biosciences, Rice UniversityFor synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.https://doi.org/10.1038/s41467-017-02473-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett
spellingShingle	Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors Nature Communications
author_facet	Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett
author_sort	Ye Chen
title	Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
title_short	Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
title_full	Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
title_fullStr	Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
title_full_unstemmed	Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
title_sort	tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.
url	https://doi.org/10.1038/s41467-017-02473-5
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Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors

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