Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors

Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors

For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.

Bibliographic Details
Main Authors: Ye Chen, Joanne M. L. Ho, David L. Shis, Chinmaya Gupta, James Long, Daniel S. Wagner, William Ott, Krešimir Josić, Matthew R. Bennett
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02473-5
Description
Summary:For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.
ISSN:2041-1723

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