TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.

The mechanisms that underlie the critical dendritic cell (DC) function in maintainance of peripheral immune tolerance are incompletely understood, although the β-catenin signaling pathway is critical for this role. The molecular details by which β-catenin signaling is regulated in DCs are unknown. M...

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Bibliographic Details
Main Authors: Bryan Vander Lugt, Zachary T Beck, Robert C Fuhlbrigge, Nir Hacohen, James J Campbell, Marianne Boes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3098869?pdf=render