How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression.

How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression.

Changes in extracellular matrix (ECM) structure or mechanics can actively drive cancer progression; however, the underlying mechanism remains unknown. Here we explore whether this process could be mediated by changes in cell shape that lead to increases in genetic noise, given that both factors have...

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Bibliographic Details
Main Authors: Justin Werfel, Silva Krause, Ashley G Bischof, Robert J Mannix, Heather Tobin, Yaneer Bar-Yam, Robert M Bellin, Donald E Ingber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24098430/?tool=EBI

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