The antibody genetics of multiple sclerosis: comparing next-generation sequencing to Sanger sequencing

The antibody genetics of multiple sclerosis: comparing next-generation sequencing to Sanger sequencing

We previously identified a distinct mutation pattern in the antibody genes of B cells isolated from cerebrospinal fluid (CSF) that can identify patients who have relapsing-remitting multiple sclerosis (RRMS) and patients with clinically isolated syndromes (CIS) that will convert to RRMS. This antibo...

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Bibliographic Details
Main Authors: William eRounds, Ann eLigocki, Mikhail eLevin, Benjamin eGreenberg, Doug eBigwood, Eric eEastman, Lindsay eCowell, Nancy eMonson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Neurology
Subjects:
Multiple Sclerosis
B cell
Next-generation sequencing
antibody
Roche 454
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00166/full

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