Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin.

Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin.

BACKGROUND: Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been...

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Bibliographic Details
Main Authors: Christoph Beitzinger, Anika Bronnhuber, Kerstin Duscha, Zsuzsanna Riedl, Markus Huber-Lang, Roland Benz, György Hajós, Holger Barth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688708?pdf=render

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