Acetoacetate enhancement of glucose mediated DNA glycation

Acetoacetate enhancement of glucose mediated DNA glycation

Acetoacetate (AA) is a ketone body, which generates reactive oxygen species (ROS). ROS production is impacted by the formation of covalent bonds between amino groups of biomacromolecules and reducing sugars (glycation). Glycation can damage DNA by causing strand breaks, mutations, and changes in gen...

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Bibliographic Details
Main Authors: M. Bagherzadeh-Yazdi, M. Bohlooli, M. Khajeh, F. Ghamari, M. Ghaffari-Moghaddam, N. Poormolaie, A. Khatibi, P. Hasanein, N. Sheibani
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Glycated DNA
Advanced glycation end products
Amadori products
Acetoacetate
Ketone body
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301886

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http://www.sciencedirect.com/science/article/pii/S2405580820301886

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