The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles

• Main Authors: Yen Yung-Chieh, Kao Wei-Tsung, Lung For-Wey
• Format: Article
• Language: English
• Published: BMC 2008-05-01
• Series: Lipids in Health and Disease
• Online Access: http://www.lipidworld.com/content/7/1/20

<p>Abstract</p> <p>Background</p> <p>Explore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and β2 adrenergic receptor (β2-AR) gene polymorphisms and lipid profiles in an elderly Chinese population.</p> <p>Methods</p> <p>Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E, PLA2 and β2-AR gene polymorphisms and lipid profiles. Two hundred sixty-seven participants agreed to have venous blood drawn for DNA studies.</p> <p>Results</p> <p>Two statistically significant differences were noted in TC and LDL-C in the Gln27Glu of the β2-AR gene polymorphism (P = 0.007, P = 0.022). The low-income group had a higher HDL-C level (p = 0.076). The Gln27Glu polymorphism Glu/Glu or Gln/Glu subjects had lower TC levels compared to the Gln27Glu polymorphism Gln/Gln subjects (p = 0.092). Lower TC levels (p = 0.082) and lower LDL-C levels (p = 0.045) in subjects with the Cys¹⁹Arg¹⁶Glu²⁷haplotype. Lower TC levels (p = 0.06) were also noted in subjects with the Cys¹⁹Gly ¹⁶Glu²⁷haplotype. On the other hand, higher VLDL-C levels (p = 0.185) and higher triglyceride (TG) levels (p = 0.190) were noted in subjects with the Cys¹⁹Gly ¹⁶Gln²⁷haplotype. The ε2 allele combined with low income had a positive effect on HDL-C (p = 0.0011), after adding the income factor in this study.</p> <p>Conclusion</p> <p>When the effects of Apo E and PLA2 on lipid profiles were included in this study, β2-AR gene polymorphisms reduced significant effect on lipid profiles. Similarly, low income increased effect on HDL-C. This study appeared that the results of gene-gene and gene-environment interaction, it should be considered in further studies for lipid profiles.</p>