Mechanisms of cardiac arrhythmias

Blood circulation is the result of the beating of the heart, which provides the mechanical force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral tissues. This depends critically on the preceding electrical activation. Disruptions in the orderly pattern of this propagati...

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Main Author:	Gary Tse, MA, MBBS, PhD
Format:	Article
Language:	English
Published:	Wiley 2016-04-01
Series:	Journal of Arrhythmia
Subjects:	Arrhythmogenic mechanisms Focal activity Reentry Ion channelopathy Sudden cardiac death
Online Access:	http://www.sciencedirect.com/science/article/pii/S1880427615001647

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spelling	doaj-9ef0520b97d243c4a923bf9c83fdf1252020-11-24T21:36:59ZengWileyJournal of Arrhythmia1880-42762016-04-01322758110.1016/j.joa.2015.11.003Mechanisms of cardiac arrhythmiasGary Tse, MA, MBBS, PhDBlood circulation is the result of the beating of the heart, which provides the mechanical force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral tissues. This depends critically on the preceding electrical activation. Disruptions in the orderly pattern of this propagating cardiac excitation wave can lead to arrhythmias. Understanding of the mechanisms underlying their generation and maintenance requires knowledge of the ionic contributions to the cardiac action potential, which is discussed in the first part of this review. A brief outline of the different classification systems for arrhythmogenesis is then provided, followed by a detailed discussion for each mechanism in turn, highlighting recent advances in this area.http://www.sciencedirect.com/science/article/pii/S1880427615001647Arrhythmogenic mechanismsFocal activityReentryIon channelopathySudden cardiac death
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gary Tse, MA, MBBS, PhD
spellingShingle	Gary Tse, MA, MBBS, PhD Mechanisms of cardiac arrhythmias Journal of Arrhythmia Arrhythmogenic mechanisms Focal activity Reentry Ion channelopathy Sudden cardiac death
author_facet	Gary Tse, MA, MBBS, PhD
author_sort	Gary Tse, MA, MBBS, PhD
title	Mechanisms of cardiac arrhythmias
title_short	Mechanisms of cardiac arrhythmias
title_full	Mechanisms of cardiac arrhythmias
title_fullStr	Mechanisms of cardiac arrhythmias
title_full_unstemmed	Mechanisms of cardiac arrhythmias
title_sort	mechanisms of cardiac arrhythmias
publisher	Wiley
series	Journal of Arrhythmia
issn	1880-4276
publishDate	2016-04-01
description	Blood circulation is the result of the beating of the heart, which provides the mechanical force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral tissues. This depends critically on the preceding electrical activation. Disruptions in the orderly pattern of this propagating cardiac excitation wave can lead to arrhythmias. Understanding of the mechanisms underlying their generation and maintenance requires knowledge of the ionic contributions to the cardiac action potential, which is discussed in the first part of this review. A brief outline of the different classification systems for arrhythmogenesis is then provided, followed by a detailed discussion for each mechanism in turn, highlighting recent advances in this area.
topic	Arrhythmogenic mechanisms Focal activity Reentry Ion channelopathy Sudden cardiac death
url	http://www.sciencedirect.com/science/article/pii/S1880427615001647
work_keys_str_mv	AT garytsemambbsphd mechanismsofcardiacarrhythmias
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Mechanisms of cardiac arrhythmias

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