Integrated extracellular microRNA profiling for ovarian cancer screening

Integrated extracellular microRNA profiling for ovarian cancer screening

Screening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.

Bibliographic Details
Main Authors: Akira Yokoi, Juntaro Matsuzaki, Yusuke Yamamoto, Yutaka Yoneoka, Kenta Takahashi, Hanako Shimizu, Takashi Uehara, Mitsuya Ishikawa, Shun-ichi Ikeda, Takumi Sonoda, Junpei Kawauchi, Satoko Takizawa, Yoshiaki Aoki, Shumpei Niida, Hiromi Sakamoto, Ken Kato, Tomoyasu Kato, Takahiro Ochiya
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06434-4
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spelling doaj-9ee9265b86e642b7b64def2709e6a9c92021-05-11T09:40:35ZengNature Publishing GroupNature Communications2041-17232018-10-019111010.1038/s41467-018-06434-4Integrated extracellular microRNA profiling for ovarian cancer screeningAkira Yokoi0Juntaro Matsuzaki1Yusuke Yamamoto2Yutaka Yoneoka3Kenta Takahashi4Hanako Shimizu5Takashi Uehara6Mitsuya Ishikawa7Shun-ichi Ikeda8Takumi Sonoda9Junpei Kawauchi10Satoko Takizawa11Yoshiaki Aoki12Shumpei Niida13Hiromi Sakamoto14Ken Kato15Tomoyasu Kato16Takahiro Ochiya17Division of Molecular and Cellular Medicine, National Cancer Center Research InstituteDivision of Molecular and Cellular Medicine, National Cancer Center Research InstituteDivision of Molecular and Cellular Medicine, National Cancer Center Research InstituteDepartment of Gynecology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDivision of Molecular and Cellular Medicine, National Cancer Center Research InstituteNew Frontiers Research Institute, Toray IndustriesNew Frontiers Research Institute, Toray IndustriesDivision of Bioinformatics, Dynacom Co., Ltd.Medical Genome Center, National Center for Geriatrics and GerontologyDepartment of Clinical Genomics, Fundamental Innovative Oncology Core, National Cancer Center Research InstituteDepartment of Gastrointestinal Medical Oncology, National Cancer Center HospitalDepartment of Gynecology, National Cancer Center HospitalDivision of Molecular and Cellular Medicine, National Cancer Center Research InstituteScreening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.https://doi.org/10.1038/s41467-018-06434-4
collection DOAJ
language English
format Article
sources DOAJ
author Akira Yokoi
Juntaro Matsuzaki
Yusuke Yamamoto
Yutaka Yoneoka
Kenta Takahashi
Hanako Shimizu
Takashi Uehara
Mitsuya Ishikawa
Shun-ichi Ikeda
Takumi Sonoda
Junpei Kawauchi
Satoko Takizawa
Yoshiaki Aoki
Shumpei Niida
Hiromi Sakamoto
Ken Kato
Tomoyasu Kato
Takahiro Ochiya
spellingShingle Akira Yokoi
Juntaro Matsuzaki
Yusuke Yamamoto
Yutaka Yoneoka
Kenta Takahashi
Hanako Shimizu
Takashi Uehara
Mitsuya Ishikawa
Shun-ichi Ikeda
Takumi Sonoda
Junpei Kawauchi
Satoko Takizawa
Yoshiaki Aoki
Shumpei Niida
Hiromi Sakamoto
Ken Kato
Tomoyasu Kato
Takahiro Ochiya
Integrated extracellular microRNA profiling for ovarian cancer screening
Nature Communications
author_facet Akira Yokoi
Juntaro Matsuzaki
Yusuke Yamamoto
Yutaka Yoneoka
Kenta Takahashi
Hanako Shimizu
Takashi Uehara
Mitsuya Ishikawa
Shun-ichi Ikeda
Takumi Sonoda
Junpei Kawauchi
Satoko Takizawa
Yoshiaki Aoki
Shumpei Niida
Hiromi Sakamoto
Ken Kato
Tomoyasu Kato
Takahiro Ochiya
author_sort Akira Yokoi
title Integrated extracellular microRNA profiling for ovarian cancer screening
title_short Integrated extracellular microRNA profiling for ovarian cancer screening
title_full Integrated extracellular microRNA profiling for ovarian cancer screening
title_fullStr Integrated extracellular microRNA profiling for ovarian cancer screening
title_full_unstemmed Integrated extracellular microRNA profiling for ovarian cancer screening
title_sort integrated extracellular microrna profiling for ovarian cancer screening
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description Screening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.
url https://doi.org/10.1038/s41467-018-06434-4
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