Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

Abstract Background Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate directed against DLL3, showed promising results. A pr...

Full description

Bibliographic Details
Main Authors: Luka Brcic, Christian Kuchler, Sylvia Eidenhammer, Daniela Pabst, Franz Quehenberger, Adi F. Gazdar, Helmut Popper
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Diagnostic Pathology
Subjects:
Small cell carcinoma
Large cell neuroendocrine carcinoma
Cell culture
DLL3
TP53
RB1
Online Access:http://link.springer.com/article/10.1186/s13000-019-0827-z

Internet

http://link.springer.com/article/10.1186/s13000-019-0827-z

Similar Items