Global stability of age-of-infection multiscale HCV model with therapy

• Main Authors: Xiaowen Xiong, Yanqiu Li, Bingliang Li
• Format: Article
• Language: English
• Published: AIMS Press 2021-04-01
• Series: Mathematical Biosciences and Engineering
• Subjects: ultiscale hcv model; infection age; therapy; lyapunov functional; global stability
• Online Access: http://www.aimspress.com/article/doi/10.3934/mbe.2021110http://www.aimspress.com/article/doi/10.3934/mbe.2021110

In order to treat the diseases caused by hepatitis C virus (HCV) more efficiently, the concentration of HCV in blood, cells, tissues and the body has attracted widespread attention from related scholars. This paper studies a dynamic dependent HCV model (more specifically, including age structure and treatment methods model) that concludes states of infection-free and infected equilibrium. Through eigenvalue analysis and Volterra integral formula, it proves that $ E_0 $ is globally asymptotically stable when $ \mathcal{R} < 1 $. After explaining the existence, uniqueness and positive properties of the solution of the system, we have proved the global asymptotic stability of $ E^* $ when $ \mathcal{R} > 1 $ by constructing a suitable Lyapunov function. Through the above proofs, it can be concluded that effective treatment measures can significantly reduce the number of HCVs, so many related researchers are aware of the importance of highly efficient nursing methods and are committed to applying relevant methods to practice.