DNA damage and mutation. Types of DNA damage
This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the intr...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2014-02-01
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| Series: | BioDiscovery |
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| Online Access: | https://biodiscovery.pensoft.net/article/8957/download/pdf/ |
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Article |
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doaj-9ed2e147bc3849cb9868ea2d8dba97192020-11-25T01:34:22ZengPensoft PublishersBioDiscovery2050-29662014-02-011114410.7750/BioDiscovery.2014.11.18957DNA damage and mutation. Types of DNA damageStoyan ChakarovRumena PetkovaGeorge Ch RussevNikolai ZhelevThis review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the introduction of heritable mutation/s are reviewed. The major features of the role of DNA damage in ageing and carcinogenesis are outlined and the role of iatrogenic DNA damage in human health and disease (with curative intent as well as a long-term adverse effect of genotoxic therapies) are discussed in detail.https://biodiscovery.pensoft.net/article/8957/download/pdf/DNA damageDNA mutation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stoyan Chakarov Rumena Petkova George Ch Russev Nikolai Zhelev |
| spellingShingle |
Stoyan Chakarov Rumena Petkova George Ch Russev Nikolai Zhelev DNA damage and mutation. Types of DNA damage BioDiscovery DNA damage DNA mutation |
| author_facet |
Stoyan Chakarov Rumena Petkova George Ch Russev Nikolai Zhelev |
| author_sort |
Stoyan Chakarov |
| title |
DNA damage and mutation. Types of DNA damage |
| title_short |
DNA damage and mutation. Types of DNA damage |
| title_full |
DNA damage and mutation. Types of DNA damage |
| title_fullStr |
DNA damage and mutation. Types of DNA damage |
| title_full_unstemmed |
DNA damage and mutation. Types of DNA damage |
| title_sort |
dna damage and mutation. types of dna damage |
| publisher |
Pensoft Publishers |
| series |
BioDiscovery |
| issn |
2050-2966 |
| publishDate |
2014-02-01 |
| description |
This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the introduction of heritable mutation/s are reviewed. The major features of the role of DNA damage in ageing and carcinogenesis are outlined and the role of iatrogenic DNA damage in human health and disease (with curative intent as well as a long-term adverse effect of genotoxic therapies) are discussed in detail. |
| topic |
DNA damage DNA mutation |
| url |
https://biodiscovery.pensoft.net/article/8957/download/pdf/ |
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AT stoyanchakarov dnadamageandmutationtypesofdnadamage AT rumenapetkova dnadamageandmutationtypesofdnadamage AT georgechrussev dnadamageandmutationtypesofdnadamage AT nikolaizhelev dnadamageandmutationtypesofdnadamage |
| _version_ |
1725072749691404288 |