From Form to Function: The role of Nox4 in the Cardiovascular System

From Form to Function: The role of Nox4 in the Cardiovascular System

The NADPH oxidase (Nox) family of proteins is comprised of 7 members, including Noxes 1-5 and the Duoxes 1 and 2. Nox4 is readily distinguished from the other Nox isoforms by its high level of expression in cardiovascular tissues and unique enzymatic properties. Nox4 is constitutively active and the...

Full description

Bibliographic Details
Main Authors:	Feng eChen, Stephen eHaigh, Scott A Barman, David eFulton
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-11-01
Series:	Frontiers in Physiology
Subjects:	NADPH Oxidase Reactive Oxygen Species NOX4 Subcellular localization H2O2 cardiovascular disease.
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00412/full

Similar Items

Cloning, Characteristics and Functional Analysis of Rabbit NADPH Oxidase 5
by: Feng Chen, et al.
Published: (2016-07-01)

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action
by: Joana Reis, et al.
Published: (2020-05-01)

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice
by: Flávia Rezende, et al.
Published: (2018-05-01)

Deletion of NoxO1 limits atherosclerosis development in female mice
by: Giulia K. Buchmann, et al.
Published: (2020-10-01)

Protein Disulfide Isomerase expression increases in resistance arteries during hypertension development. Effects on Nox 1 NADPH oxidase signaling
by: Aline Cristiane Depoli Androwiki, et al.
Published: (2015-03-01)

Nox2 activation in Covid-19
by: Francesco Violi, et al.
Published: (2020-09-01)

THE EFFECTS OF P22PHOX GENETIC POLYMORPHISMS AND NATURAL COMPOUNDS ON REACTIVE OXYGEN SPECIES FORMATION
by: Whitehouse, Scott David
Published: (2013)

NOX, NOX who is there?, The contribution of NADPH Oxidase to beta cell dysfunction.
by: David eTaylor-Fishwick
Published: (2013-04-01)

NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis
by: Misaki Matsumoto, et al.
Published: (2021-06-01)

NADPH Oxidase 5 and Melatonin: Involvement in Ram Sperm Capacitation
by: Sara Miguel-Jiménez, et al.
Published: (2021-05-01)

Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System
by: Yasuhisa Ano, et al.
Published: (2012-06-01)

Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension
by: David J.R. Fulton, et al.
Published: (2017-07-01)

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
by: Qin Liya, et al.
Published: (2012-01-01)

Nox4 Maintains Blood Pressure during Low Sodium Diet
by: Flávia Rezende, et al.
Published: (2021-07-01)

Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
by: Siu-Lung eChan, et al.
Published: (2013-06-01)

Oxyradical Stress, Endocannabinoids, and Atherosclerosis
by: Anberitha T. Matthews, et al.
Published: (2015-12-01)

The Fundamental Role of NOX Family Proteins in Plant Immunity and Their Regulation
by: Ya-Jing Wang, et al.
Published: (2016-05-01)

Reactive Oxygen Species Rewires Metabolic Activity in Acute Myeloid Leukemia
by: Andrew J. Robinson, et al.
Published: (2021-03-01)

Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models
by: Leticia Guadalupe Fragoso-Morales, et al.
Published: (2021-02-01)

Plant signaling networks involving Ca2+ and Rboh/Nox-mediated ROS production under salinity stress
by: Takamitsu eKurusu, et al.
Published: (2015-06-01)

Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
by: Tim Schader, et al.
Published: (2020-09-01)

Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
by: Chih-Fen Hu, et al.
Published: (2021-04-01)

Mechanisms for suppressing NADPH oxidase in the vascular wall
by: Gregory J Dusting, et al.
Published: (2005-03-01)

Selective inhibition of NADPH oxidase reverses the over contraction of diabetic rat aorta
by: Atif ur Rehman, et al.
Published: (2014-01-01)

Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques
by: Shaoping Xu, et al.
Published: (2014-01-01)

A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD
by: Dong-Hee Choi, et al.
Published: (2017-11-01)

Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics
by: Kai Huang, et al.
Published: (2021-01-01)

Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
by: Ana Caroline Paiva Gandara, et al.
Published: (2017-03-01)

Reactive oxygen species derived from NOX3 and NOX5 drive differentiation of human oligodendrocytes
by: Roberta eAccetta, et al.
Published: (2016-06-01)

Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice
by: Alejandra Z. Vielma, et al.
Published: (2020-07-01)

NADPH Oxidases: The Vital Performers and Center Hubs during Plant Growth and Signaling
by: Chun-Hong Hu, et al.
Published: (2020-02-01)

The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice
by: Giulia K. Buchmann, et al.
Published: (2021-09-01)

The Role of NADPH oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts
by: Shuang eLiang, et al.
Published: (2016-02-01)

NADPH Oxidases: Redox Regulators of Stem Cell Fate and Function
by: Tullia Maraldi, et al.
Published: (2021-06-01)

Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair
by: Dominik André-Lévigne, et al.
Published: (2017-10-01)

Identification de nouveaux facteurs de régulation physiopathologique de la NADPH oxydase du neutrophile : Importance de mTOR, de la dégradation de NOX2 via l’élastase et perspectives de traitement des déficits induits au cours de la cirrhose alcoolique
by: Rolas, Loïc
Published: (2015)

PKCδ-Mediated Nox2 Activation Promotes Fluid-Phase Pinocytosis of Antigens by Immature Dendritic Cells
by: Bhupesh Singla, et al.
Published: (2018-03-01)

Role of NOX/ROS in 5-HT-mediated proliferation of rat pulmonary artery smooth muscle cells
by: ZHANG Ying, et al.
Published: (2020-12-01)

The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox
by: Edna eBechor, et al.
Published: (2015-02-01)

Sistema NADPH oxidasa: nuevos retos y perspectivas = NADPH oxidase system: new challenges and perspectives
by: Arango Rincón, Julián Camilo, et al.
Published: (2010-12-01)

Cannot write session to /tmp/vufind_sessions/sess_cdhctucr1csmvvdipiejn2jdma