MAOA haplotypes associated with thrombocyte-MAO activity
<p>Abstract</p> <p>Background</p> <p>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO locus and validated gene...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-09-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/6/46 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).</p> <p>Results</p> <p>Our results reveal a profound SNP desert in the <it>MAOB </it>gene. Both the <it>MAOA </it>and <it>MAOB </it>genes segregate as two distinct LD blocks. We found a significant association between two <it>MAOA </it>gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.</p> <p>Conclusion</p> <p>The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males.</p> |
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| ISSN: | 1471-2156 |