Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL−/− mice were more suscep...

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Bibliographic Details
Main Authors: Shui-Xing Yu, Wei Chen, Zhen-Zhen Liu, Feng-Hua Zhou, Shi-Qing Yan, Gui-Qiu Hu, Xiao-Xia Qin, Jie Zhang, Ke Ma, Chong-Tao Du, Jing-Min Gu, Xu-Ming Deng, Wen-Yu Han, Yong-Jun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
mixed lineage kinase-like protein
inflammasome
gasdermin D
Salmonella
colitis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00119/full

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