| Summary: | In the posthaemorragic period in the different bloodloss volume, experimental examination of the erythropoetic activity of the red bone marrow was made. An analysis of the effectiveness of the use of recombinant erythropoietin (rEPO) was also done. In the experiments pubertal Wistar line rats were used. Were experimented the following parameters of erythropoesis in the red bone marrow: the quantitative density of erythropoetic cells, relative quantity of erythroblasts with micronuclei, mitotic index of erythropoetic cells, relative quantity of reticulocytes in the structure of erythropoetic cells and the relative quantity of erythropoetic islets in the state of reconstruction. The analysis of these parameters showed that in blood loss of small level. The peak of erythropoesis stimulation comes on the third day of the posthaemorragic period, and in rats with moderate level of bleeding – on the seventh day. The depression of the erythropoetic activity of the red bone marrow in the first seven days of experiment in rats with severe level of blood loss was revealed. The use of rEPO brought on a great stimulation of erythropoesis in rats with blood loss of moderate and severe degrees in the first seven days after using the preparation. The use of rEPO in animals with small level of blood loss was not effective. A rising of the volume of the blood loss brought on an authentic rising amount of erythroblasts with micronuclei and with the use of rEPO this parameter had a tendency to an authen-tic lowering.
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