Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases: potential implications for canalicular bile formation1

Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases: potential implications for canalicular bile formation1

Both phosphatidylcholine (PC) and sphingomyelin (SM) are the major phospholipids in the outer leaflet of the hepatocyte canalicular membrane. Yet, the phospholipids secreted into bile consist principally (>95%) of PC. In order to understand the physical–chemical basis for preferential biliary PC...

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Bibliographic Details
Main Authors: Erik R.M. Eckhardt, Antonio Moschetta, Willem Renooij, Soenita S. Goerdayal, Gerard P. van Berge-Henegouwen, Karel J. van Erpecum
Format: Article
Language:English
Published: Elsevier 1999-11-01
Series:Journal of Lipid Research
Subjects:
bile salts
canalicular membrane
cholesterol
differential scanning calorimetry
intermixed micellar/vesicular bile salt concentration
micelles
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324263

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http://www.sciencedirect.com/science/article/pii/S0022227520324263

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