Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells

Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells

Abstract Background Acquired resistance remains a limitation of the clinical use of 5-fluorouracil (5-FU). Because exosomes, are important vesicles participating in intercellular communication, their contribution to the development of acquired 5-FU resistance needs to be elucidated. In this study, w...

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Bibliographic Details
Main Authors: Qian Zhang, Rui-Xian Liu, Ka-Wo Chan, Jiancong Hu, Jingdan Zhang, Lili Wei, Huiliu Tan, Xiangling Yang, Huanliang Liu
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
P-STAT3
Exosomes
5-FU resistance
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1314-9

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