Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function.

Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function.

Myocardial fibrosis, a major pathophysiologic substrate of heart failure with preserved ejection fraction (HFPEF), is modulated by multiple pathways including the renin-angiotensin system. Direct renin inhibition is a promising anti-fibrotic therapy since it attenuates the pro-fibrotic effects of re...

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Bibliographic Details
Main Authors:	Hui Zhi, Ivan Luptak, Gaurav Alreja, Jianru Shi, Jian Guan, Nicole Metes-Kosik, Jacob Joseph
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3859492?pdf=render

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