Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms

Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms

Many proteins involved in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS) are remarkably similar to proteins that form prions in the yeast Saccharomyces cerevisiae. These ALS-associated proteins are not orthologs of yeast prion proteins, but are similar in having long, intrinsically...

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Bibliographic Details
Main Authors: Zachary T. Monahan, Shannon N. Rhoads, Debra S. Yee, Frank P. Shewmaker
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
prion
FUS
TAF15
HNRNPA2B1
EWSR1
TDP-43
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00453/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00453/full

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