Genome-wide analysis of miRNA signature differentially expressed in doxorubicin-resistant and parental human hepatocellular carcinoma cell lines.

Chemotherapy regiments have been widely used in the treatment of a variety of human malignancies including hepatocellular carcinoma (HCC). A major cause of failure in chemotherapy is drug resistance of cancer cells. Resistance to doxorubicin (DOX) is a common and representative obstacle to treat can...

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Bibliographic Details
Main Authors: Jufeng Zhang, Ying Wang, Pingping Zhen, Xia Luo, Chao Zhang, Lin Zhou, Yanxin Lu, Yang Yang, Wei Zhang, Jun Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554743?pdf=render